實(shí)驗(yàn)室研究方向：

T cells play essential roles in immune response. We are studying T cells with two directions:

1. Functional genomics in primary T cells

We are applying genome-wide CRISPR/Cas9 screen in primary T cell in vivo to answer fundamental questions in T cell biology, including development, activation, proliferation and differentiation, as well as T cell fitness (e.g. exhaustion) in tumor microenvironment.  Identified novel genes and regulatory circuits have been used to design novel therapies for diseases.

2. Mechanisms of metabolic regulation of T cells

Metabolic reprogramming is a hallmark of T cell activation, but how metabolic pathways regulate T cell function remains poorly understood. We are using mouse models with gain- and loss-of-function of key metabolic enzymes to decipher metabolic regulation T cell, and try to target metabolism to treat immune-related diseases.

近期代表性成果如下，

1. Min Peng, Na Yin, Ming O. Li. SZT2 dictates GATOR control of mTORC1 signaling. Nature. 2017 Mar 16;543(7645):433-437. 

2. Min Peng*, Na Yin*, Sagar Chhangawala, Ke Xu, Christina S. Leslie, Ming O. Li. Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism. Science, 2016 Oct 28; 354(6311): 481-484. *equal contribution. 

Preview in Science, 2016 Oct 28; 354(6311): 419-420. “Warburg meets epigenetics”. 

Preview in Dev Cell, 2016 November 7;39: 286-287. “Metabolic Control of Cellular Differentiation”.

Preview in Cell Metab, 2016 November 8; 24: 651-652. “Metabolic Signaling Drives IFN-g”.

3. Min Peng, Na Yin, Ming O. Li. Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling. Cell. 2014 Sep 25; 159(1): 122-33. 

Highlighted in Nat Rev Mol Cell Biol, 2014; 15: 701, “A RAG dissociation inhibitor”.

博士后 招聘1-2名： 

應(yīng)聘條件：具有免疫學(xué)、分子和細(xì)胞生物學(xué)相關(guān)專(zhuān)業(yè)博士學(xué)位，獲得博士學(xué)位1年以?xún)?nèi)；近期以第一作者身份在國(guó)際知名學(xué)術(shù)期刊發(fā)表研究論文，符合清華大學(xué)博士后入站標(biāo)準(zhǔn)，年齡小于35周歲；熱愛(ài)科研工作，責(zé)任心強(qiáng)，具備團(tuán)隊(duì)合作精神；具備較好的英語(yǔ)溝通、閱讀和寫(xiě)作能力。

崗位待遇：在清華大學(xué)校定博士后工資待遇基礎(chǔ)上，根據(jù)工作經(jīng)驗(yàn)和能力可以享受具有國(guó)際競(jìng)爭(zhēng)力的年薪式津貼。符合條件者，支持申請(qǐng)國(guó)家“博新計(jì)劃”、清華“水木學(xué)者”、以及生命科學(xué)聯(lián)合中心博士后獎(jiǎng)學(xué)金支持計(jì)劃。

申請(qǐng)方式：將簡(jiǎn)歷（包括學(xué)歷和論文發(fā)表情況）、研究自述（研究興趣、成果以及未來(lái)職業(yè)規(guī)劃）、及2-3名推薦人的聯(lián)系方式發(fā)至：pengmin@tsinghua.edu.cn；主題標(biāo)明“姓名+應(yīng)聘博士后 “。

為防止簡(jiǎn)歷投遞丟失請(qǐng)抄送一份至：boshijob@126.com（郵件標(biāo)題格式：應(yīng)聘職位名稱(chēng)+姓名+學(xué)歷+專(zhuān)業(yè)+中國(guó)博士人才網(wǎng)）