簡介

科比爾卡創(chuàng)新藥物開發(fā)研究院（KIIDD）是香港中文大學(xué)（深圳）組建的首批諾貝爾獎科學(xué)家實驗室之一。研究院的重點研究領(lǐng)域集中在新藥開發(fā)上，研究方向主要包括藥物受體結(jié)構(gòu)生物學(xué)研究、藥物計算化學(xué)研究、功能藥物分子的有機合成和藥物化學(xué)的研究、受體功能藥物分子的功能藥理學(xué)等。通過X射線單晶衍射、核磁共振和冷凍電子顯微學(xué)等方法進行藥物受體結(jié)構(gòu)生物學(xué)研究，借助計算機輔助和分子模擬進行藥物設(shè)計，對功能藥物分子合成和藥物化學(xué)、藥理學(xué)原理進行研究，進行對新型藥物進行合成制備，為今后的臨床研究提供藥理學(xué)理論支撐。

本次招聘的崗位隸屬于香港中文大學(xué)（深圳）科比爾卡冷凍電子顯微中心，它是KIIDD在深圳市龍崗區(qū)政府的大力支持下，歷時一年打造的高性能冷凍電子顯微平臺，也是龍崗區(qū)第一個結(jié)構(gòu)生物學(xué)平臺。中心致力于建設(shè)成具有國際一流核心技術(shù)和分析能力的高端科研平臺，與世界頂尖高校開展深度合作與交流，推動研究院產(chǎn)學(xué)研創(chuàng)新和突破，開展龍崗區(qū)和深圳在相關(guān)領(lǐng)域的產(chǎn)業(yè)化和項目轉(zhuǎn)化。

科比爾卡冷凍電子顯微中心是由提供有償服務(wù)的設(shè)施，工作人員在將冷凍電鏡成像應(yīng)用于他們的研究中的過程中，為研究院的研究發(fā)展提供專業(yè)支持。中心與科研人員緊密合作，確定最佳的實驗設(shè)計方案，包括樣品制備策略，維護和操作低溫電子顯微鏡以及輔助設(shè)備以提供高分辨率圖像，以及在數(shù)據(jù)管理和分析方面提供指導(dǎo)和服務(wù)。

職位描述

工作職責(zé)：

•幫助維護和操作冷凍電子顯微鏡如Titan Krios及相關(guān)設(shè)備

•幫助定期進行電鏡流程測試并優(yōu)化電鏡性能以進行數(shù)據(jù)收集

•參與冷凍電鏡的方法開發(fā)/優(yōu)化

•與具有不同經(jīng)驗水平的用戶互動/對其進行培訓(xùn)

•維護設(shè)施日常運行記錄

崗位要求：

•結(jié)構(gòu)生物學(xué)，生物化學(xué)，生物物理學(xué)，材料科學(xué)或相關(guān)領(lǐng)域的博士，有經(jīng)驗的碩士也將考慮

•2-3年的cryo-EM經(jīng)驗，包括處理樣品，使用顯微鏡和圖像評估

•了解透射電子顯微鏡和3D結(jié)構(gòu)確定的原理

•對cryo-EM工作流程的有一般了解

•樂于學(xué)習(xí)新技術(shù)并應(yīng)對新挑戰(zhàn)

•愿意參加開發(fā)/測試新方法/技術(shù)

•團隊協(xié)作能力，溝通能力強

申請程序

請準(zhǔn)備好完整的中、英文簡歷發(fā)送至郵箱：liuzheng@cuhk.edu.cn，郵件標(biāo)題注明：應(yīng)聘崗位+本人姓名+學(xué)位+畢業(yè)學(xué)校+所學(xué)專業(yè) 

Brief Introduction

Kobilka Institute of Innovative Drug Discovery is one of the first batch of Nobel laureate labs at the University. Led by Prof. Brian K. Kobilka, the Nobel laureate in Chemistry in 2012, the Kobilka Institute of Innovative Drug Discovery (KIIDD) is a significant milestone in the University's attempt to evolve into a world research university.

KIIDD will focus on new drug development which includes drugs receptor structural biology research, computational chemistry research, the function of the drug molecules in organic synthesis and medicinal chemistry research, receptor function the function of the drug molecule pharmacology, etc. Researchers in KIIDD are going to carry out studies about the structural biology of drug receptors through lots of modern biological techniques, such as single crystal x-ray diffraction, Nuclear magnetic resonance (NMR) and electron microscopy. CAD and molecular simulations were used in the drug designs. KIIDD lay eyes on functional drug synthesis, medicinal chemistry and pharmacology, to further explore the pathways to make new drugs, as well as offering intellectual support on pharmacology for future clinical research.

The Kobilka Cryo-EM center is a fee-for-service facility operated by the KIIDD at Chinese University of Hongkong(Shenzhen) as a state-of-the-art shared resource for biomedical researchers. The Cryo-EM staff members develop and provide their knowledge and expertise to the research community at KIIDD in applying cryo-EM imaging to their research. They work closely with investigators to define optimal experimental design including strategies for preparation of samples, maintain and operate cryo-electron microscopes and ancillary equipment in order to provide high resolution images, and provide guidance and service in data management and analysis.

The successful candidate will assist facility staff with maintenance and operation of the advanced instrumentation housed in the Cryo-EM core and will work with and train users in specimen preparation. The candidate will also be responsible for record keeping associated with users, instrument logs, and routine operation of the facility. The candidate will be expected to learn new procedures as they are developed and implemented by the facility.

Post Specification

Preferred Qualifications:

• M.S in structural biology, biophysics, biochemistry, material science or related field, Ph.D would be a plus

• 2-3 years of experience in cryo-EM including handling samples, using microscopes and evaluation of images

• Knowledge of the principles of transmission electron microscopy and 3D structure determination

• General understanding of cryo-EM workflow

• Excellent communication and interpersonal skills

• Motivated to learn new technologies and to take on new challenges

• Willing to develop/test new methods/techniques

• Excellent organizational skills and record keeping

• Special consideration will be given to candidates with a record of achievement in collaborative, team-driven environments

Responsibilities:

• Help maintain and operate cryo electron microscopes and related equipment

• Regularly benchmark and optimize microscope performance for data collection

• Participate in method developments/optimization for cryo-EM

• Interact closely with/train users with different levels of experience

• Maintain record of daily operations in the facility

Application Procedure

Please send a full curriculum vitae by email to liuzheng@cuhk.edu.cn

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