Post-doctoral Research Scientist in dopamine and astrocyte biology in health and Parkinson’s disease

University of Oxford

Description

The Cragg Group at the University of Oxford have been awarded a MRC Project Grant to explore the role of astrocytes in the regulation of dopamine function in health and parkinsonism. We are now seeking to appoint a Postdoctoral Research Scientist to work as part of this exciting collaboration.

The successful candidate will become a member of the Cragg group and will have responsibility for developing, executing, analysing and reporting primarily on studies to elucidate dopamine transmission, its regulation and dysregulation by activity in astrocytes, related cells and signalling molecules in mouse brain. There will be a focus on elucidating the control of dopamine neurotransmission using real-time methods like fast-scan cyclic voltammetry and imaging of fluorescent reporters, in brain slices in mouse models of Parkinson's disease. The candidate will also collaborate on projects with the Cragg Group's internal and external partners and when appropriate, undertake the training and supervision of other members of the Group. The candidate will be responsible for acquiring, analyzing and interpreting scientific data, ensuring that the data are of the highest quality.

In addition to having, or nearing completion of, a PhD/M.D. or equivalent  qualification in a relevant discipline, candidates should have a promising track record of original research in their particular field of neuroscience. Candidates are also expected to have technical expertise in real-time electrochemical or electrophysiology recordings in brain slices, in neurosurgery, with rodents and to provide evidence of creative and critical thinking as applied to the delivery of a focused programme of research. Experience of fluorescence imaging is also desirable.

The post holder will work in the Group led by Professor Stephanie Cragg, and will be based at the Department of Physiology, Anatomy and Genetics, Sherrington Building, Parks Road, Oxford, OX1 3PT.

This is a full-time, fixed-term post available until 18 April 2024 funded by the MRC. Owing to the nature of this position, any offer of employment with the University will be subject to a satisfactory security screening.

Informal enquiries can be addressed to Stephanie.cragg@dpag.ox.ac.uk.

Closing date for applications is noon on Tuesday 15th March 2022.

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