Postdoctoral Associate in Neuroscience : London, United Kingdom
We are seeking three highly motivated individuals to work at the interface of molecular, systems and computational neuroscience. These positions form part of a new collaboration between UCL, University of Oxford, and the Karolinska Institute. The aim of this project is to understand the great diversity of cell types present in cortex, and their roles in cortical circuits and in the resulting computations. While the three positions require diverse skill sets, all offer the opportunity to work as part of a closely integrated, multidisciplinary team focused on solving one of the most important challenges in current neuroscience.
Position 1: Molecular analysis of cortical tissue
The successful applicant will apply novel multiplexed RNA analysis techniques to cortical tissue, to characterize the molecular fingerprints of distinct cortical cell types. This position would suit a scientist with experience of molecular biology, as well as strong knowledge and interest in systems neuroscience. Prior experience of in situ RNA methods would be beneficial but is not essential for outstanding applicants. The successful applicant will be based initially in Stockholm to learn and refine the novel molecular techniques to be used, and will then move to London to apply them to tissue previously studied in vivo with two-photon calcium imaging.
Position 2: In vivo recording
The successful applicant will use two-photon microscopy with genetically encoded calcium sensors to record from large neuronal populations in subjects performing behavioral tasks, which will then be subjected to post-hoc molecular analysis. In addition to experimental recordings, this position will involve computational work to analyze the large amount of data produced by these experiments. This position would suit a scientist with experience of experimental neurophysiology as well as strong quantitative/computational skills. Prior experience with two-photon microscopy would be beneficial but is not essential for outstanding applicants. The position will be based in London.
Position 3: Computational analysis and modeling
The successful applicant will develop new computational methods to process the large amounts of data arising from these experiments, and to use it to build computational models of cortical circuit interactions. The data arising from the project is diverse, consisting of images, video, and high-dimensional gene expression vectors. Analysis of this unique data set will require a combination of techniques including digital image processing, machine learning, as well as neural circuit modeling. The position would suit a candidate with a background in computational neuroscience, theoretical physics, computer science, mathematics, or engineering. Prior experience with digital image processing and machine learning techniques would be beneficial but is not essential for outstanding applicants. The position will be based in London.
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