Post-doctoral fellowship position available at the University of Alabama at Birmingham for candidate interested in brain tumor research related to the characterization of cancer stem cells/brain tumor initiating cells. The cancer stem cell hypothesis posits that a hierarchy exists in some cancers with self-renewing cancer stem cells generating progeny constituting the remainder of the tumor. The presence of highly tumorigenic cancer stem cells has been demonstrated for brain tumors including glioblastoma, the most lethal and prevalent primary malignant brain tumor in adults. Glioblastoma stem cells have been demonstrated to be radio- and chemoresistant as well as highly angiogenic, suggesting the importance of targeting these cells for patient therapies. We seek to better understand the molecular and biological mechanisms through which brain tumor stem cells drive tumor maintenance in order to identify novel targets for cancer therapy. Applicants should have a Ph.D in Cancer Biology, Molecular Biology, Pharmacology, Neuroscience, or a closely related field. Candidates must have prior experience with cell culture and molecular biology techniques such as purification of nucleic acids, quantitative real-time PCR, and immunoblotting. Prior experience with production of lentivirus, xenograft models, measurement of DNA repair, immunofluorescence/confocal imaging and/or isolation of primary cells desired. Applicants must be willing to work with human cells and mouse models. Must have strong organizational skills and be detail oriented. Ability to work well independently and apply scientific principles to the solution of novel problems needed. Must work well as part of a team and recognize the benefits of collaboration, taking initiative, and offering constructive criticism. Chosen candidates will be expected to work with undergraduates and technicians in the laboratory to accomplish experimental goals. In addition to data production, candidates will be expected to communicate findings via the preparation of manuscripts and grants. If interested, e-mail your cover letter, CV, and contact information for three references to Dr. Anita Hjelmeland at hjelmea@uab.edu.

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