Postdoctoral position at the Johns Hopkins School of Medicine.

A post-doctoral position is available to start immediately in the laboratory of Dr. Andrew Holland, located at the Johns Hopkins University School of Medicine, Baltimore, Maryland. Johns Hopkins School of Medicine is a world-class institution that is consistently ranked amongst the top three medical research schools in the USA.

The Holland laboratory is studying the molecular mechanisms that control accurate chromosome distribution and the role that mitotic errors play in human health and disease. Our work utilizes a combination of chemical biology, biochemistry, cell biology and genetically engineered mice to study pathways involved in mitosis and their effect on cell and organism physiology. A major focus of the group is to develop cell and animal-based models to study the role of cell division defects in genome instability and tumorigenesis.

For more details of our recent publications and research interests please visit our website at www.hollandlab.com.
The successful applicant must have, or be in the process of completing, a PhD. We welcome applications from diverse backgrounds including those with a strong interest in cell biology, biochemistry, medicine and cancer biology. We also welcome those with backgrounds in engineering, chemistry, and physics who are interested in applying their expertise to biological systems. Candidates with expertise in cell-biology, microscopy, biochemistry or the use of mouse models are strongly encouraged to apply. All candidates must be highly motivated and have a strong record of independent research

Applications should be sent to aholland@jhmi.edu and should include a letter detailing the candidate’s motivation, a full curriculum vitae including a list of publications and the names and addresses of three referees.

Relevant publications:
Holland, A, et al, (2012). The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle. Genes Dev 26, 2684-2689.

Holland, A*, Fachinetti, D.* and Cleveland, D. (2012). An inducible system for the rapid and complete destruction of proteins in mammalian cells. Proc Natl Acad Sci U S A 109, E3350-E3357.

Holland, A. and Cleveland, D. (2012). Chromoanagenesis and cancer: mechanisms and consequences of localized, complex chromosomal rearrangements. Nature Medicine 18, 1630-1638.

Holland, A. and Cleveland, D. (2012). Losing balance: the origin and impact of aneuploidy in cancer. EMBO Reports 13, 501-514.

Holland, A., et al. (2012). Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis. Mol Biol Cell 23, 1838-1845.

Kim, Y., Holland, A., et al. (2010). Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E. Cell 142, 444-455.

Holland, A., et al. (2010). Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability. J Cell Biol 188, 191-198.

Holland, A, and Cleveland, D. (2009). Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis. Nat Rev Mol Cell Biol 10, 478-487