UNIVERSITY OF SUSSEX
School of Life Sciences
Genome Damage and Stability Centre
Postdoctoral Research Fellow – 2 posts
Salary: Grade 7 (£28,290 – £33,780)
Start date: Posts available immediately
Fixed term for 3 years
Two 3-year Postdoctoral Fellowships are available in the laboratory of Dr Alessandro Bianchi to study the composition and function of the telomeric complex in budding and fission yeast cells.
Telomeres are nucleo-protein structures found at the ends of Eukaryotic chromosomes, where they carry out essential roles in DNA replication and chromosome protection. Defects in telomere function have detrimental effects on cells and also consequences for human health, affecting both the ageing process and oncogenic transformation.
The telomerase enzyme is responsible for the maintenance of telomeric DNA. In turn, telomeric DNA recruits a large number of protein factors (collectively constituting the telomeric complex) which mediates telomere function, both by regulating the action of telomerase (and orchestrating it with conventional DNA replication), and by ensuring proper chromosome protection. We are interested in deciphering the molecular mechanism by which the telomeric complex carries out its multiple functions. To this goal we will pursue several avenues, employing both genetic and biochemical approaches, primarily in the budding and fission yeast systems. There is substantial flexibility in the posts, depending on the skills of the successful applicant. The post holders should have experience in molecular and cell biology. Previous experience with yeast is preferable but not necessary.
References
Bianchi, A. and Shore D. (2008). Mol Cell, 31:153-165. (Review)
Bianchi, A., and Shore, D. (2007). Genes Dev, 21:1726-1730.
Bianchi, A., and Shore, D. (2007). Cell, 128:1051-1062.
Negrini, S., Ribaud, V., Bianchi, A., and Shore, D. (2007). Genes Dev, 21:292-302
Bianchi, A., Negrini, S, and Shore, D. (2004). Mol Cell, 16:139-146.
More information can be obtained informally from Alessandro Bianchi, Tel 00 44 1273 678 123, a.bianchi@sussex.ac.uk
Closing date for applications: 16 September 2008
For details and how to apply see: www.sussex.ac.uk/jobs
Application details are available from and should be returned to Human Resources, Sussex House, University of Sussex, Falmer, Brighton BN1 9RH. Tel: (01273) 678706, fax: (01273) 877401, Email: recruitment@sussex.ac.uk
The University of Sussex is an equal opportunities employer
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